Phenotypes for Eomes Sox1 MGI:3808022 MGI Mouse

increased exploration in new environment ( J:138764 )

• increased exploratory behavior in the open field test

increased aggression towards humans ( J:138764 )

• enhanced aggressiveness upon handling

increased aggression towards mice ( J:138764 )

• male mutants mutilated or killed pups

decreased grip strength ( J:138764 )

• significantly reduced grip strength

abnormal neuron apoptosis ( J:138764 )

• enhanced cell death in the dentate migration stream

abnormal axon guidance ( J:138764 )

• fraction of callosal axons are misrouted

• the typical input-related patterning in Barrel cortex was strongly diminished

abnormal neuronal precursor proliferation ( J:138764 )

• significant decrease of nonventricular surface proliferation during cortical development

• expression of subventricular zone (SVZ) markers were reduced indicating about 25% decrease of proliferating cells in the mutant SVZ throughout development

• neurogenesis in the dentate gyrus was completely absent

• nerurogenesis in th subependymal zone of adult mutants appeared normal

decreased brain size ( J:138764 )

• despite normal body weight, mutant brains showed a markedly reduced brain size

• the size of the cortex and the olfactory bulbs was markedly reduced at birth

absent anterior commissure ( J:138764 )

• the contralateral projecting fibers from olfactory nuclei and temporal lobes which forms the anterior commissure were absent

abnormal dentate gyrus morphology ( J:138764 )

• the infrapyramidal blade did not develop

thin cerebral cortex ( J:138764 )

• cortical layers II-IV thickness is reduced

abnormal olfactory bulb morphology ( J:138764 )

• the mitral cell layer in the olfactory bulb is absent

small olfactory bulb ( J:138764 )