Phenotypes Associated with This Genotype

Genotype
MGI:3807780

• Allelic Composition: Tg(DO11.10)10Dlo/?; Tox^tm1.1Kay/Tox^tm1.1Kay
• Genetic Background: involves: 129S/Sv * BALB/c * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

arrested T cell differentiation ( J:131287 )

• transgenic T cell development is arrested after positive selection but before CD4⁺T cell lineage commitment

decreased T cell number ( J:131287 )

• mice exhibit severe lymphopenia with only a minor population of CD8⁺ T cells found in the spleen

hematopoietic system

arrested T cell differentiation ( J:131287 )

• transgenic T cell development is arrested after positive selection but before CD4⁺T cell lineage commitment

decreased T cell number ( J:131287 )

• mice exhibit severe lymphopenia with only a minor population of CD8⁺ T cells found in the spleen