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Phenotypes Associated with This Genotype
Genotype
MGI:3807663
Allelic
Composition
Scube1tm1Rbya/Scube1tm1Rbya
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scube1tm1Rbya mutation (0 available); any Scube1 mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice die shortly after birth with acrania and lack of brain tissue

nervous system
• cranial neural folds are everted at E12.5
• at E12.5, mice exhibit a thickening of the forebrain neuroepithelium wall
• at E12.5, mice exhibit degeneration of brain tissue
• at E12.5, mice exhibit a thickening of the forebrain neuroepithelium wall
• mice exhibit exencephaly of the midbrain due to over proliferation of neural tissue and evertion of cranial neural folds
• hyperplastic at E12.5
• hyperplastic at E12.5
• hyperplastic at E12.5
• at E12.5, an increased proliferation rate is noted in the forebrain neuroepithelium, as evidenced by the number of Ki-67-positive nuclei
• however, the proliferation rate of the hindbrain neural tube is normal
• the midbrain neuroepithelium continues to proliferate in exencephalic embryos and becomes a large convoluted mass of brain tissue protruding from the head

craniofacial
• absent at E14.5
• at E12.5, mice exhibit acrania

skeleton
• absent at E14.5
• at E12.5, mice exhibit acrania

embryo
• cranial neural folds are everted at E12.5
• at E12.5, mice exhibit a thickening of the forebrain neuroepithelium wall


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory