Phenotypes Associated with This Genotype

Genotype
MGI:3807548

• Allelic Composition: Tg(H2-K-DUSP5)21Wjl/0
• Genetic Background: involves: C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ulcerative dermatitis and kidney glomerular lesions in Tg(H2-K-DUSP5)21Wjl/0 mice

mortality/aging

premature death ( J:138077 )

• death within two months of the appearance of skin lesions

immune system

decreased T cell proliferation ( J:138077 )

• in response to TCR stimulation

increased plasma cell number ( J:138077 )

abnormal T cell number ( J:138077 )

increased double-positive T cell number ( J:138077 )

• increased number of double positive thymocytes

increased CD4-positive, alpha-beta T cell number ( J:138077 )

• increased number of cells with an activated memory phenotype

increased CD8-positive, alpha-beta T cell number ( J:138077 )

• increased numbers of CD8+ memory t cells

decreased single-positive T cell number ( J:138077 )

• diminished numbers of single positive thymocytes

• reduced number of single positive splenocytes

increased single-positive T cell number ( J:138077 )

skin inflammation ( J:138077 )

• inflammatory cell infiltration

dermatitis ( J:138077 )

• ulcerative dermatitis

• epidermal damage

renal/urinary system

cortical renal glomerulopathies ( J:138077 )

• glomerular lesions found in mice with skin ulcerations

hematopoietic system

decreased T cell proliferation ( J:138077 )

• in response to TCR stimulation

increased plasma cell number ( J:138077 )

abnormal T cell number ( J:138077 )

increased double-positive T cell number ( J:138077 )

• increased number of double positive thymocytes

increased CD4-positive, alpha-beta T cell number ( J:138077 )

• increased number of cells with an activated memory phenotype

increased CD8-positive, alpha-beta T cell number ( J:138077 )

• increased numbers of CD8+ memory t cells

decreased single-positive T cell number ( J:138077 )

• diminished numbers of single positive thymocytes

• reduced number of single positive splenocytes

increased single-positive T cell number ( J:138077 )

integument

skin inflammation ( J:138077 )

• inflammatory cell infiltration

dermatitis ( J:138077 )

• ulcerative dermatitis

• epidermal damage

alopecia ( J:138077 )

• appears in about one quarter of mice

• around 14 weeks of age

skin hyperplasia ( J:138077 )

• in epithelial areas adjacent to inflammation

cellular

decreased T cell proliferation ( J:138077 )

• in response to TCR stimulation