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Phenotypes Associated with This Genotype
Genotype
MGI:3807225
Allelic
Composition		 Fzd5tm1Nat/Fzd5tm2Nat
Gt(ROSA)26Sortm1(cre/ERT)Nat/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd5tm1Nat mutation (1 available); any Fzd5 mutation (33 available)
Fzd5tm2Nat mutation (1 available); any Fzd5 mutation (33 available)
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (3 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal thalamus morphology ( J:136390 )
• PFN in adults displays nearly complete loss of alkaline phosphatase expressing Fzd5-null neurons by 10 days after 4HT injection and cre activation, but no loss is observed in Fzd5tm2Nat/+, cre-positive control PFNs 8 days after 4HT treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory