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Phenotypes Associated with This Genotype
Genotype
MGI:3806796
Allelic
Composition		 Trem2tm1Cln/Trem2tm1Cln
Genetic
Background		 B6.129P2-Trem2tm1Cln
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trem2tm1Cln mutation (0 available); any Trem2 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal interferon level ( J:138057 )
• no IFN gamma detected in response to agonists for Tlr2, 4, 6, and 9
abnormal interleukin level ( J:138057 )
• no Il12 detected in response to agonists for Tlr2, 4, 6, and 9
• increased Il6 production in response to LPS by bone marrow derived macrophage and peritoneal macrophage
abnormal tumor necrosis factor level ( J:138057 )
• increased Tnf alpha production by bone marrow derived macrophage and peritoneal macrophage in response to agonists for Tlr2, 4, 6, and 9

homeostasis/metabolism
abnormal interferon level ( J:138057 )
• no IFN gamma detected in response to agonists for Tlr2, 4, 6, and 9
abnormal interleukin level ( J:138057 )
• no Il12 detected in response to agonists for Tlr2, 4, 6, and 9
• increased Il6 production in response to LPS by bone marrow derived macrophage and peritoneal macrophage
abnormal tumor necrosis factor level ( J:138057 )
• increased Tnf alpha production by bone marrow derived macrophage and peritoneal macrophage in response to agonists for Tlr2, 4, 6, and 9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory