Trem2^tm1Cln
Targeted Allele Detail

Summary

• Symbol: Trem2^tm1Cln
• Name: triggering receptor expressed on myeloid cells 2; targeted mutation 1, Marco Colonna
• MGI ID: MGI:3806795
• Gene: Trem2 Location: Chr17:48653429-48659304 bp, + strand Genetic Position: Chr17, 23.99 cM, cytoband C
• Alliance: Trem2^tm1Cln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138057
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were replaced by a floxed neomycin selection cassette. Chimeric mice were crossed to a CMV-cre transgenic mouse to excise the neo cassette in the germline. Mice were backcrossed to C57BL/6 more than five times. (J:138057)

Expression

In Mice Carrying this Mutation:

5 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trem2 Mutation: 65 strains or lines available

References

• Original: J:138057 Turnbull IR, et al., Cutting edge: TREM-2 attenuates macrophage activation. J Immunol. 2006 Sep 15;177(6):3520-4
• All: 63 reference(s)