Phenotypes Associated with This Genotype

Genotype
MGI:3806622

• Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi; Sqstm1^tm1Keta/Sqstm1^tm1Keta; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating alanine transaminase level ( J:130839 )

• slightly eleveated levels of ALT are found in the sera after Cre-induction but not to the degree of conditional knockouts with wild-type Sqstm1 alleles

increased circulating alkaline phosphatase level ( J:130839 )

• high levels of ALP are found in the sera after Cre-induction but not to the degree of conditional knockouts with wild-type Sqstm1 alleles

increased circulating aspartate transaminase level ( J:130839 )

• slightly elevated levels of AST are found in the sera after Cre-induction but not to the degree of conditional knockouts with wild-type Sqstm1 alleles

liver/biliary system

abnormal hepatocyte morphology ( J:130839 )

• the cytoplasmic inclusion bodies containing ubiquitinated proteins that are associated with Atg7 conditional liver knockout mice are almost completely absent in these mice

decreased liver function ( J:130839 )

• liver function is slightly decreased after Cre-induction but not to the degree of conditional knockouts with wild-type Sqstm1 alleles