Phenotypes for Drd1 Gad1 MGI:3806595 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Drd1^tm1(cre)Rpa/Drd1⁺ Gad1^tm1Rpa/Gad1^tm1.1Rpa
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd1^tm1(cre)Rpa mutation (0 available); any Drd1 mutation (72 available)
Gad1^tm1.1Rpa mutation (0 available); any Gad1 mutation (65 available)
Gad1^tm1Rpa mutation (1 available); any Gad1 mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:138586 )

N	• mice exhibit normal gait and response to the Drd1a agonist SKF81297

limb grasping ( J:138586 )

abnormal motor coordination/balance ( J:138586 )

• mice spend more time on a rotarod than heterozygous controls

decreased grip strength ( J:138586 )

• on the second of three trials mice exhibit decreased strength in a modified wire hang test compared to heterozygous controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/28/2026 MGI 6.24