Phenotypes Associated with This Genotype

Genotype
MGI:3806328

• Allelic Composition: Gt(ROSA)26Sor^tm1(tTA)Roos/?; Lhx3^tm1(cre)Slp/Lhx3⁺; Tg(tetO-SOD1*G93A,-luc)1Roos/0
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:138761 )

N • mice show no significant differences relative to triple mutants carrying wild-type human SOD1, in the rotarod test when tested at 300 days and later

decreased motor neuron number ( J:138761 )

• significant decrease in number of spinal motor neurons (MNs) compared to wild-type and transgenic controls is observed at 450 days of age

abnormal ventral spinal root morphology ( J:138761 )

• significant decrease in number of axons in L5 anterior root at 450 days is observed compared to triple mutants expressing wild-type human SOD1

growth/size/body

decreased body weight ( J:138761 )

• after 300 days, mean body weight is reduced relative to wild-type or to triple mutants carrying the wild-type human SOD1 gene