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Phenotypes Associated with This Genotype
Genotype
MGI:3806251
Allelic
Composition		 Droshatm1Litt/Droshatm1.1Litt
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Droshatm1.1Litt mutation (0 available); any Drosha mutation (98 available)
Droshatm1Litt mutation (3 available); any Drosha mutation (98 available)
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (3 available); any Gt(ROSA)26Sor mutation (1062 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal interferon-gamma secretion ( J:138683 )
• naive CD4+ T cells release more interferon gamma than controls after cre-mediated deletion of Rnasen induced by tamoxifen treatment
• deficient CD4+ T cells are capable of differentiating into Th1 or Th2 cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory