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Phenotypes Associated with This Genotype
Genotype
MGI:3806100
Allelic
Composition		 C3tm1Hrc/C3tm1Hrc
Cd55tm1Song/Cd55tm1Song
Cr1ltm1Hmo/Cr1ltm1Hmo
Genetic
Background		 involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Hrc mutation (2 available); any C3 mutation (102 available)
Cd55tm1Song mutation (2 available); any Cd55 mutation (39 available)
Cr1ltm1Hmo mutation (0 available); any Cr1l mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal platelet physiology ( J:138410 )
• transplanted platelets exhibit a decreased half-life compared to wild-type platelets that is complement and macrophage dependent
• however, transgenic expression of Cd55 rescues platelet half-life following transplantation

homeostasis/metabolism
abnormal platelet physiology ( J:138410 )
• transplanted platelets exhibit a decreased half-life compared to wild-type platelets that is complement and macrophage dependent
• however, transgenic expression of Cd55 rescues platelet half-life following transplantation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory