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Phenotypes Associated with This Genotype
Genotype
MGI:3805877
Allelic
Composition		 Ptentm1Mro/Ptentm1Mro
Tg(Pcp2-cre)756Mro/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Mro mutation (1 available); any Pten mutation (87 available)
Tg(Pcp2-cre)756Mro mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellar Purkinje cell layer ( J:77123 )
• mice exhibit subtle irregularities in the Purkinje cell lining compared to in wild-type mice
abnormal Purkinje cell morphology ( J:77123 )
• increased in size compared to in wild-type mice
Purkinje cell degeneration ( J:77123 )
• at 17 and 20 weeks
abnormal Purkinje cell dendrite morphology ( J:77123 )
• dendrites and descending axons are thickened compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory