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Phenotypes Associated with This Genotype
Genotype
MGI:3805865
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (17 available); any Pten mutation (87 available)
Tg(Pbsn-cre)4Prb mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased prostate gland tumor incidence ( J:142106 )
• mutants develop tumors between 12 to 20 weeks, with 100% penetrance at 20 weeks
increased prostate gland adenocarcinoma incidence ( J:142106 )
• all mice develop invasive adenocarcinoma in all prostate lobes
• malignant cells invade through the basement membrane into the adjacent stroma, inducing both an inflammatory and a desmoplastic response, resulting in growth of fibrous and connective tissue around the tumor
increased prostate intraepithelial neoplasia incidence ( J:138565 )
• mice develop prostate intraepithelial neoplasias

reproductive system
increased prostate gland tumor incidence ( J:142106 )
• mutants develop tumors between 12 to 20 weeks, with 100% penetrance at 20 weeks
increased prostate gland adenocarcinoma incidence ( J:142106 )
• all mice develop invasive adenocarcinoma in all prostate lobes
• malignant cells invade through the basement membrane into the adjacent stroma, inducing both an inflammatory and a desmoplastic response, resulting in growth of fibrous and connective tissue around the tumor
increased prostate intraepithelial neoplasia incidence ( J:138565 )
• mice develop prostate intraepithelial neoplasias

endocrine/exocrine glands
increased prostate gland tumor incidence ( J:142106 )
• mutants develop tumors between 12 to 20 weeks, with 100% penetrance at 20 weeks
increased prostate gland adenocarcinoma incidence ( J:142106 )
• all mice develop invasive adenocarcinoma in all prostate lobes
• malignant cells invade through the basement membrane into the adjacent stroma, inducing both an inflammatory and a desmoplastic response, resulting in growth of fibrous and connective tissue around the tumor
increased prostate intraepithelial neoplasia incidence ( J:138565 )
• mice develop prostate intraepithelial neoplasias

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory