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Phenotypes Associated with This Genotype
Genotype
MGI:3805864
Allelic
Composition		 Pik3catm1Jjz/Pik3catm1Jjz
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3catm1Jjz mutation (1 available); any Pik3ca mutation (64 available)
Tg(Pbsn-cre)4Prb mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:138565 )
• following cre-mediated recombination, mouse embryonic fibroblasts (MEFs) undergo reduced levels of immortalization upon exposure to HRas-G12V or EGFR-Del from feeder cells

neoplasm
increased prostate intraepithelial neoplasia incidence ( J:138565 )
• mice develop prostate intraepithelial neoplasias

reproductive system
increased prostate intraepithelial neoplasia incidence ( J:138565 )
• mice develop prostate intraepithelial neoplasias

endocrine/exocrine glands
increased prostate intraepithelial neoplasia incidence ( J:138565 )
• mice develop prostate intraepithelial neoplasias

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory