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Phenotypes Associated with This Genotype
Genotype
MGI:3805821
Allelic
Composition		 Bmi1tm1(cre/ERT)Mrc/Bmi1+
Ctnnb1tm1Mmt/Ctnnb1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmi1tm1(cre/ERT)Mrc mutation (2 available); any Bmi1 mutation (31 available)
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:138364 )
• mice die 50 days following administration of tamoxifen

neoplasm
increased intestinal adenoma incidence ( J:138364 )
• beginning 22 days following administration of tamoxifen

digestive/alimentary system
abnormal crypts of Lieberkuhn morphology ( J:138364 )
• the number of proliferating cells within crypts is increased 15 days following administration of tamoxifen
increased intestinal adenoma incidence ( J:138364 )
• beginning 22 days following administration of tamoxifen

endocrine/exocrine glands
abnormal crypts of Lieberkuhn morphology ( J:138364 )
• the number of proliferating cells within crypts is increased 15 days following administration of tamoxifen

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory