Analysis Tools
hematopoietic system
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• platelet ATP levels are much lower than in C57BL/6J controls
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• platelet ADP levels are much lower than in C57BL/6J controls
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• fewer platelet dense granules than normal
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• less than 7% of normal levels of platelet serotonin
(J:7327)
• platelet serotonin level is also lower than that of control when fed an atherogenic diet
(J:29748)
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homeostasis/metabolism
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• platelet ATP levels are much lower than in C57BL/6J controls
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• less than 7% of normal levels of platelet serotonin
(J:7327)
• platelet serotonin level is also lower than that of control when fed an atherogenic diet
(J:29748)
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• bleed time averaging over 15 minutes after tail nick is much greater than the 3.8 minutes for C57BL/6J controls
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cardiovascular system
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• on an atherogenic diet homozygotes develop fewer aortic lesions and smaller lesions than C57BL/6J controls
• 60% of homozygotes survive to 48 weeks of age on an atherogenic diet, when no C57BL/6J controls survive, and, although there are significant atherosclerotic lesions in these 48 week old homozygotes, the lesions are smaller than those in 39 week old C57BL/6J controls fed the atherogenic diet
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integument
pigmentation
nervous system
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• the ipsilateral lateral geniculate nucleus has fewer projections from the retinal ganglion cells
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• there is a reduced number of projections of retinal ganglion cells to the ipsilateral lateral geniculate nucleus
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vision/eye
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• there is a reduced number of projections of retinal ganglion cells to the ipsilateral lateral geniculate nucleus
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renal/urinary system
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• concentration of lysosomal enzymes is elevated
• decreased rate of secretion of lysosomal enzyme into urine
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cellular
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• platelet ATP levels are much lower than in C57BL/6J controls
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Hermansky-Pudlak syndrome 6 | DOID:0060544 |
OMIM:614075 |
J:81444 | |
| platelet storage pool deficiency | DOID:2223 |
OMIM:185050 |
J:7327 | |
