nervous system
• mice exhibit condensation of the molecular layer
• the molecular layer in the cerebellum is atrophic
|
• astrocytes are hypertrophied with numerous processes
|
astrocytosis
(
J:125549
)
• marked
|
• dendritic processes in the CA1 region of the hippocampus exhibit collapse, vacuolization and reduction in complexity
• Purkinje dendritic processes are tortuous, dilated and exhibit reduced branching
|
• dendritic processes are tortuous, dilated and exhibit reduced branching
|
• neuronal damage
|
behavior/neurological
• mice exhibit less severe neurological defects than observed in founder mice
|
paraparesis
(
J:125549
)
• hindlimb weakness
|
immune system
N |
• despite neuronal damage, mice do not exhibit encephalitis or meningitis
|
cardiovascular system
• marked in the cerebellum
|
• mice exhibit descrete perivasculitis in a small number of larger blood vessels in the cerebellar sulci
|
growth/size/body
• at 1 to 2 weeks of age
|
integument
ruffled hair
(
J:125549
)