Phenotypes Associated with This Genotype

Genotype
MGI:3804816

• Allelic Composition: Mib1^tm2Kong/Mib1^tm2Kong; Tg(Msx2-cre)5Rem/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

syndactyly ( J:130369 )

fused phalanges ( J:130369 )

• digits 2 through 4 are fused in adulthood

• mice exhibit fusion of soft tissues and nails of digits 2 and 3

abnormal digit development ( J:130369 )

• at E13.5, the interdigit space between digits 2 and 3 is narrower than in wild-type mice

abnormal interdigital cell death ( J:130369 )

• at E15.5, interdigit separation is absent due to a decrease in interdigital cell death

growth/size/body

epidermal cyst ( J:130369 )

• at P28, mice exhibit epidermal cysts below the interfollicular epidermis that are filled with cornified materials

decreased body size ( J:130369 )

skeleton

fused phalanges ( J:130369 )

• digits 2 through 4 are fused in adulthood

• mice exhibit fusion of soft tissues and nails of digits 2 and 3

integument

hairless ( J:130369 )

• mice are bald at 4 weeks of age

premature hair loss ( J:130369 )

• mice begin to lose their hair along the dorsal midline and bald at 4 weeks of age

decreased hair follicle number ( J:130369 )

• at 28 days, hair follicles are barely detected in the back skin

abnormal epidermal layer morphology ( J:130369 )

• at P28, the epidermal cell layer has numerous squame

epidermal cyst ( J:130369 )

• at P28, mice exhibit epidermal cysts below the interfollicular epidermis that are filled with cornified materials

thick epidermis ( J:130369 )

• at P28

cellular

abnormal interdigital cell death ( J:130369 )

• at E15.5, interdigit separation is absent due to a decrease in interdigital cell death