Analysis Tools
mortality/aging
|
• mice die at around E11.5
|
embryo
|
• at E9.5 and E10.5
|
|
• at E9.5 and E10.5
|
|
• at E9.5 and E10.5, mice exhibit defects characteristic of vascular remodeling
|
cardiovascular system
| N |
• despite defects in vascular remodeling, vasculogenesis is normal
|
|
• the dorsal aorta is narrower than in wild-type mice and arterial specification is abnormal
|
|
• capillary networks are less extensive and more primitive than in wild-type mice
|
|
• at E9.5 and E10.5
|
|
• at E9.5 and E10.5
|
hematopoietic system
|
• cultures of para-aortic splanchnopleura produce fewer colony forming cells when cultured alone or on OP9 cells compared to cultured wild-type cells
|
growth/size/body
|
• at E9.5 and E10.5
|
homeostasis/metabolism
|
• at E9.5 and E10.5
|
cellular
|
• capillary networks are less extensive and more primitive than in wild-type mice
|
