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Phenotypes Associated with This Genotype
Genotype
MGI:3804190
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Tcf3tm1Mbu/Tcf3tm1.2Mbu
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Tcf3tm1.2Mbu mutation (0 available); any Tcf3 mutation (48 available)
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the bone marrow, pro-B and re-circulating B cell numbers are decreased by half compared to in wild-type mice
• in the bone marrow, total B cell number in the bone marrow is reduced to 30% of wild-type
• the spleen contains half the number of B cells as in wild-type mice
• in the bone marrow, immature B cells are decreased to 18% of wild-type numbers
• in the spleen, immature B cells are reduced by 50% compared to in wild-type mice
• in the spleen, transitional B cells are reduced by 50% compared to in wild-type mice
• in the spleen, mature B cells are reduced by 50% compared to in wild-type mice
• in the bone marrow, pre-B cells are decreased to 18% of wild-type numbers
• GFP+ pre-B cells are absent in the bone marrow

hematopoietic system
• in the bone marrow, pro-B and re-circulating B cell numbers are decreased by half compared to in wild-type mice
• in the bone marrow, total B cell number in the bone marrow is reduced to 30% of wild-type
• the spleen contains half the number of B cells as in wild-type mice
• in the bone marrow, immature B cells are decreased to 18% of wild-type numbers
• in the spleen, immature B cells are reduced by 50% compared to in wild-type mice
• in the spleen, transitional B cells are reduced by 50% compared to in wild-type mice
• in the spleen, mature B cells are reduced by 50% compared to in wild-type mice
• in the bone marrow, pre-B cells are decreased to 18% of wild-type numbers
• GFP+ pre-B cells are absent in the bone marrow


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory