Phenotypes Associated with This Genotype

Genotype
MGI:3804182

• Allelic Composition: Dag1^tm2Kcam/Dag1^tm2Kcam; Tg(Mpz-cre)26Mes/0
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal myelin sheath morphology ( J:137852 )

• abnormally folded myelin with loops, infolding and outfolding is seen in sciatic nerves

demyelination ( J:137852 )

• hypomyelination of the ventral roots

• decrease in myelination becomes evident with age and at 12 months of age includes signs of acute demyelination, myelin degeneration, macrophage infiltration, and remyelination

abnormal action potential ( J:137852 )

• reduced motor action potential amplitude

abnormal nerve conduction ( J:137852 )

decreased nerve conduction velocity ( J:137852 )