Phenotypes Associated with This Genotype

Genotype
MGI:3803973

• Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa; Tg(Lck-Akt1*)M-1Pnt/0
• Genetic Background: involves: 129S/SvEv * C3H/He * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased double-positive T cell number ( J:135903 )

• 96% of thymocytes are double positive

• the presence of the transgene rescues the block of T cell development that occurs at DN3 in Rag2^tm1Fwa homozygotes

absent CD4-positive, alpha-beta T cells ( J:135903 )

• despite the presence of double positive thymocytes, single positive T cells do not develop

absent CD8-positive, alpha-beta T cells ( J:135903 )

• despite the presence of double positive thymocytes, single positive T cells do not develop

hematopoietic system

increased double-positive T cell number ( J:135903 )

• 96% of thymocytes are double positive

• the presence of the transgene rescues the block of T cell development that occurs at DN3 in Rag2^tm1Fwa homozygotes

absent CD4-positive, alpha-beta T cells ( J:135903 )

• despite the presence of double positive thymocytes, single positive T cells do not develop

absent CD8-positive, alpha-beta T cells ( J:135903 )

• despite the presence of double positive thymocytes, single positive T cells do not develop