Phenotypes Associated with This Genotype

Genotype
MGI:3803972

• Allelic Composition: Akt1^tm1Pnt/Akt1^tm1Pnt; Akt2^tm1.1Mbb/Akt2^tm1.1Mbb; Akt3^tm1Mbb/Akt3^tm1Mbb; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased T cell apoptosis ( J:135903 )

• double negative thymocytes of all stages have higher rates of apoptosis

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 20-fold

increased double-negative T cell number ( J:135903 )

• the percentage of double negative T cells in the thymus is 85.4% compared to 2.7% in wild-type mice

• there is a significant reduction in proliferating DN4 cells suggesting a partial development block in transitioning to the DP stage

decreased double-positive T cell number ( J:135903 )

• the percentage of double positive T cells in the thymus is reduced to 1.8% compared to 84.6% in wild-type mice

• the actual number of DP T cells is 50-fold less than is found in wild-type thymuses

arrested T cell differentiation ( J:135903 )

• developing thymocytes are almost completely blocked at the DN4 to DP transition

immune system

increased T cell apoptosis ( J:135903 )

• double negative thymocytes of all stages have higher rates of apoptosis

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 20-fold

increased double-negative T cell number ( J:135903 )

• the percentage of double negative T cells in the thymus is 85.4% compared to 2.7% in wild-type mice

• there is a significant reduction in proliferating DN4 cells suggesting a partial development block in transitioning to the DP stage

decreased double-positive T cell number ( J:135903 )

• the percentage of double positive T cells in the thymus is reduced to 1.8% compared to 84.6% in wild-type mice

• the actual number of DP T cells is 50-fold less than is found in wild-type thymuses

arrested T cell differentiation ( J:135903 )

• developing thymocytes are almost completely blocked at the DN4 to DP transition

cellular

increased T cell apoptosis ( J:135903 )

• double negative thymocytes of all stages have higher rates of apoptosis

endocrine/exocrine glands

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 20-fold