Phenotypes Associated with This Genotype

Genotype
MGI:3803971

• Allelic Composition: Akt1^tm1Pnt/Akt1^tm1Pnt; Akt2^tm1.1Mbb/Akt2^tm1.1Mbb; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell apoptosis ( J:135903 )

• an increased percentage of double positive thymocytes are apoptotic (15.9% compared to 2.6%)

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 15-fold

increased double-negative T cell number ( J:135903 )

• the percentage of double negative T cells in the thymus is 56.2% compared to 2.7% in wild-type mice

• there is a significant reduction in proliferating DN4 cells suggesting a partial development block in transitioning to the DP stage

decreased double-positive T cell number ( J:135903 )

• the percentage of double positive T cells in the thymus is reduced to 25% compared to 84.6% in wild-type mice

• the actual number of DP T cells is 50-fold less than is found in wild-type thymuses

arrested T cell differentiation ( J:135903 )

• developing thymocytes are partially blocked at the DN3 to DN4 stage and the DN4 to the DP stage

hematopoietic system

increased T cell apoptosis ( J:135903 )

• an increased percentage of double positive thymocytes are apoptotic (15.9% compared to 2.6%)

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 15-fold

increased double-negative T cell number ( J:135903 )

• the percentage of double negative T cells in the thymus is 56.2% compared to 2.7% in wild-type mice

• there is a significant reduction in proliferating DN4 cells suggesting a partial development block in transitioning to the DP stage

decreased double-positive T cell number ( J:135903 )

• the percentage of double positive T cells in the thymus is reduced to 25% compared to 84.6% in wild-type mice

• the actual number of DP T cells is 50-fold less than is found in wild-type thymuses

arrested T cell differentiation ( J:135903 )

• developing thymocytes are partially blocked at the DN3 to DN4 stage and the DN4 to the DP stage

cellular

increased T cell apoptosis ( J:135903 )

• an increased percentage of double positive thymocytes are apoptotic (15.9% compared to 2.6%)

endocrine/exocrine glands

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 15-fold