Phenotypes Associated with This Genotype

Genotype
MGI:3802922

• Allelic Composition: Fbxw7^tm1Iaai/Fbxw7^tm1Iaai; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129/Sv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

thymus hypoplasia ( J:137138 )

• 4 weeks after treatment with pIpC thymus cellularity is decreased compared to in wild-type mice

• however, thymus cellularity after 2 weeks of treatment with pIpC is normal

abnormal T cell differentiation ( J:137138 )

• at 2 and 4 weeks after treatment with pIpC, the numbers of early T cell progenitors is decreased compared to in wild-type mice

decreased double-negative T cell number ( J:137138 )

• following treatment with pIpC, double negative relative and absolute cell numbers are decreased compared to in wild-type mice

• following treatment with pIpC, DN2 and DN3 cells are almost completely absent

decreased bone marrow cell number ( J:137138 )

• following treatment with pIpC

decreased hematopoietic stem cell number ( J:137138 )

• following treatment with pIpC, the number of LSK (lineage - Sca-1 + c-Kit +) cells is decreased 3- to 5-fold in the bone marrow compared to in wild-type mice

• following treatment with pIpC, the number of LSKcells is decreased in the blood and spleen compared to in wild-type mice

• defects in stem cell renewal are cell-autonomous

• following treatment with pIpC, LSK cell cycling is accelerated with loss of quiescence compared to in wild-type mice

• following treatment with pIpC, cultured progenitor cells exhibit reduced colony forming capacity and a loss of self-renewal compared to wild-type cells

• however, the relative abundance of common, megakaryocyte-erythrocyte, and granulocyte-monocyte progenitors and cell cycling of more differentiated progenitor cells than lSK cells are normal

immune system

thymus hypoplasia ( J:137138 )

• 4 weeks after treatment with pIpC thymus cellularity is decreased compared to in wild-type mice

• however, thymus cellularity after 2 weeks of treatment with pIpC is normal

abnormal T cell differentiation ( J:137138 )

• at 2 and 4 weeks after treatment with pIpC, the numbers of early T cell progenitors is decreased compared to in wild-type mice

decreased double-negative T cell number ( J:137138 )

• following treatment with pIpC, double negative relative and absolute cell numbers are decreased compared to in wild-type mice

• following treatment with pIpC, DN2 and DN3 cells are almost completely absent

endocrine/exocrine glands

thymus hypoplasia ( J:137138 )

• 4 weeks after treatment with pIpC thymus cellularity is decreased compared to in wild-type mice

• however, thymus cellularity after 2 weeks of treatment with pIpC is normal