Analysis Tools
mortality/aging
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• some mice die at or around birth of cardiovacsular abnormalities
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behavior/neurological
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• mice freeze less than wild-type mice in a contextual fear-conditioning test
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• mice freeze less than wild-type mice in a cued fear-conditioning test
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• mice exhibit decreased arm choice accuracy compared to wild-type mice
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• male mice, but not female mice, travel more I the margins and less in the center of an open field compared to wild-type males
• in a light-dark transition test, male mice spend more time in the dark phase than wild-type male mice
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nervous system
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• mice exhibit a reduction in the number and size of dendritic spines and decreased dendritic complexity of CA1 pyramidal neurons compared to in wild-type mice
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• mice exhibit a deficit in prepulse inhibition compared to in wild-type mice
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cardiovascular system
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• some mice die at or around birth of cardiovacsular abnormalities
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