Phenotypes Associated with This Genotype

Genotype
MGI:3802653

• Allelic Composition: Del(2Hoxd11-Hoxd13)29Ddu/+; Hoxd13^spdh/Hoxd13⁺
• Genetic Background: involves: 129S2/SvPas * C3HeB/FeJLe * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

ectrodactyly ( J:71694 )

• less pronounced than in homozygotes of either component mutation

polydactyly ( J:71694 )

• variable syndactyly of digits III and IV, along with a supernumerary digit in between

syndactyly ( J:71694 )

abnormal digit development ( J:71694 )

reproductive system

reduced male fertility ( J:71694 )

♂ • although males homozygous for either mutation are sterile, approximately 60% of these trans-heterozygotes are fertile

skeleton

delayed endochondral bone ossification ( J:71694 )

• at 8 days of age the paws have some delay in the ossification process although ossification centers are observed