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Phenotypes Associated with This Genotype
Genotype
MGI:3801488
Allelic
Composition
Mecp2tm1Pplt/Mecp2+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Pplt mutation (0 available); any Mecp2 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• motor defect on initial exposure to rotarod test
• rotarod performance normalized when maintained in an "enriched" environment
• rotarod performance improves over 5 days of training
• rotarod performance remains deficient relative to wild-type kept in a standard environment
• coordination improvement acquired with training is lost in the weeks subsequent to training
• "enriched" environment prevents coordination deficiency from developing
• reduced rearing activity regardless of the environment

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:137344


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory