Phenotypes Associated with This Genotype

Genotype
MGI:3801168

• Allelic Composition: Fzr1^tm1.1Mama/Fzr1⁺
• Genetic Background: involves: BALB/cJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:137456 )

• survival compared to wild-type mice decreases after 25 months of age with all mice dead by 30 months

neoplasm

decreased incidence of tumors by chemical induction ( J:137456 )

• young mice develop fewer and smaller tumors in a classical skin carcinogenesis protocol (DMBA and TPA induction) compared to similarly treated wild-type mice

decreased tumor growth/size ( J:137456 )

• young mice develop fewer and smaller tumors in a classical skin carcinogenesis protocol (DMBA and TPA induction) compared to similarly treated wild-type mice

increased tumor incidence ( J:137456 )

• aged mice develop more frequent epithelial neoplasias such as mammary adenocarcinomas and fibroadenomas (in females) as well as tumors in the lung, liver, kidney, testis and sebaceous glands compared to wild-type mice

increased mammary gland tumor incidence ( J:137456 )

• aged female mice develop mammary adenocarcinomas and fibroadenomas more frequently than wild-type mice

increased mammary adenocarcinoma incidence ( J:137456 )

• in aged female mice

increased testis tumor incidence ( J:137456 )

♂ • in aged mice

increased liver tumor incidence ( J:137456 )

• in aged mice

increased lung tumor incidence ( J:137456 )

• in aged mice

nervous system

abnormal postnatal subventricular zone morphology ( J:137456 )

• mice exhibit increased proliferation in cells of the subventricular zone

• however, no alterations in brain structures are detected

behavior/neurological

abnormal object recognition memory ( J:137456 )

• object recognition is reduced compared to in wild-type mice

abnormal motor coordination/balance ( J:137456 )

• mice exhibit increased falling off of a circular rod compared to wild-type mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:137456 )

• young mice develop fewer and smaller tumors in a classical skin carcinogenesis protocol (DMBA and TPA induction) compared to similarly treated wild-type mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:137456 )

• aged female mice develop mammary adenocarcinomas and fibroadenomas more frequently than wild-type mice

increased mammary adenocarcinoma incidence ( J:137456 )

• in aged female mice

increased testis tumor incidence ( J:137456 )

♂ • in aged mice

reproductive system

increased testis tumor incidence ( J:137456 )

♂ • in aged mice

integument

increased mammary gland tumor incidence ( J:137456 )

• aged female mice develop mammary adenocarcinomas and fibroadenomas more frequently than wild-type mice

increased mammary adenocarcinoma incidence ( J:137456 )

• in aged female mice

respiratory system

increased lung tumor incidence ( J:137456 )

• in aged mice

liver/biliary system

increased liver tumor incidence ( J:137456 )

• in aged mice