Phenotypes Associated with This Genotype

Genotype
MGI:3801082

• Allelic Composition: Cd207^{tm1(Hbegf/EGFP)Bjec}/Cd207⁺
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased dendritic cell number ( J:137452 )

• following intratracheally treatment with diphtheria toxin, CD11b-CD11c^hi dendritic ccells are depleted in the lungs

absent Langerhans cell ( J:137517 )

• following treatment with diphtheria toxin, mice exhibit a rapid and complete ablation of Langerhans cells and recovery does not occur for 4 weeks

decreased susceptibility to type IV hypersensitivity reaction ( J:137517 )

• following treatment with diphtheria toxin

increased susceptibility to Orthomyxoviridae infection ( J:137452 )

• following intratracheally administration of diphtheria toxin, mice exhibit increased severity of influenza infection, increased weight lose and delayed clearance compared to infected wild-type mice

hematopoietic system

decreased dendritic cell number ( J:137452 )

• following intratracheally treatment with diphtheria toxin, CD11b-CD11c^hi dendritic ccells are depleted in the lungs

absent Langerhans cell ( J:137517 )

• following treatment with diphtheria toxin, mice exhibit a rapid and complete ablation of Langerhans cells and recovery does not occur for 4 weeks