Analysis Tools
homeostasis/metabolism
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• chylomicron clearance from the plasma is almost twice as fast as occurs in wild-type mice
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• total cholesterol levels are reduced by 25% in female mice and about 15% in male mice
• cholesterol levels in female mice fed a high-fat diet for 5 months rise significantly less than in wild-type controls
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• HDL cholesterol levels are reduced by 15% in female but not male mice
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• VLDL+LDL cholesterol levels are reduced by half in female but not male mice
• VLDL+LDL cholesterol levels in female mice fed a high-fat diet for 5 months rise significantly less than in wild-type controls
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• VLDL+LDL cholesterol levels are reduced by half in female but not male mice
• VLDL+LDL cholesterol levels in female mice fed a high-fat diet for 5 months rise significantly less than in wild-type controls
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• plasma triglycerides are reduced by 15% in both female and male mice
• triglyceride levels remain low after acute fat loading tests compared to wild-type mice that have sharp increases in triglyceride levels
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