Phenotypes Associated with This Genotype

Genotype
MGI:3800811

• Allelic Composition: Tg(APOA1)1Rub/?; Tg(APOA2)3Rub/?
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:92450 , J:129704 )

• HDL particle size has a broad size distribution between 8 and 9.5 nm but is missing the 10.5 nm particles observed in mice carrying just the Tg(APOA1)1Rub transgene (J:92450)

• HDL particle size has a broad size distribution similar to human HDL particles that contain apoA-I and apoA-II (J:129704)

cardiovascular system

decreased susceptibility to atherosclerosis ( J:129704 )

• there is a 2.7-fold reduction in the mean lesion area found in the aorta of mice fed an atherogenic diet for 36 weeks compared to wild-type mice