Phenotypes Associated with This Genotype

Genotype
MGI:3800806

• Allelic Composition: Fas^lpr/Fas^lpr; Selplg^tm1Fur/Selplg^tm1Fur
• Genetic Background: MRL.Cg-Selplg^tm1Fur Fas^lpr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:127199 )

• overall survival is reduced compared to Fas^lpr homozygotes (median survival is 21 weeks vs 26 weeks for Fas mutants); renal lesions are severe at time of death

immune system

abnormal chemokine level ( J:127199 )

• significant increases are observed at 16 weeks, in contrast to Selp-null, Fas double mutants; levels are significantly higher than control at 20 weeks

glomerulonephritis ( J:127199 )

• at 20 weeks of age, kidneys display higher lesion scores than controls

dermatitis ( J:127199 )

• double mutants show more rapid onset of cutaneous inflammation than Fas^lpr homozygotes

renal/urinary system

glomerulonephritis ( J:127199 )

• at 20 weeks of age, kidneys display higher lesion scores than controls

homeostasis/metabolism

abnormal chemokine level ( J:127199 )

• significant increases are observed at 16 weeks, in contrast to Selp-null, Fas double mutants; levels are significantly higher than control at 20 weeks

integument

dermatitis ( J:127199 )

• double mutants show more rapid onset of cutaneous inflammation than Fas^lpr homozygotes