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Phenotypes Associated with This Genotype
Genotype
MGI:3800776
Allelic
Composition		 Cd4tm1Mak/Cd4tm1Mak
Cd8atm1Mak/Cd8atm1Mak
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Mak mutation (5 available); any Cd4 mutation (85 available)
Cd8atm1Mak mutation (7 available); any Cd8a mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to viral infection ( J:110749 )
• virus is still detectable in bone marrow, heart, and other organs 1 month after polyomavirus infection compared to controls that clear the infection by one month

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory