Phenotypes Associated with This Genotype

Genotype
MGI:3800670

• Allelic Composition: \C3^tm1Crr/\C3^tm1Crr; \C4b^tm1Crr/\C4b^tm1Crr; \Fas^lpr/\Fas^lpr
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:127292 )

• spleen mass is significantly increased relative to C3-null, Fas^lpr or single Fas^lpr mutants at 17 weeks of age

enlarged cervical lymph nodes ( J:127292 )

• lymph node mass is increased relative to C3-null, Fas^lpr or single Fas^lpr mutants at 10 and 13 weeks of age

abnormal immune system physiology ( J:127292 )

• frequency of antibody-secreting cells (ASCs) or antibody-forming cells (AFCs) is significantly increased in spleen, bone marrow, and lymph nodes compared to C3-deficient Fas mutants or single Fas^lpr mutants

increased anti-nuclear antigen antibody level ( J:127292 )

• titers of serum ANA are significantly increased at 10 and 17 weeks, compared to single-deficient mice

increased anti-double stranded DNA antibody level ( J:127292 )

• anti-dsDNA titers are elevated significantly relative to C4, Fas double mutants

hematopoietic system

enlarged spleen ( J:127292 )

• spleen mass is significantly increased relative to C3-null, Fas^lpr or single Fas^lpr mutants at 17 weeks of age

renal/urinary system

abnormal kidney morphology ( J:127292 )

• increased IgG deposition relative to C3/Fas mutants is observed in kidney sections; deposition is similar to C4/Fas mutants

abnormal renal glomerulus morphology ( J:127292 )

• more severe glomerular abnormalities are observed relative to C3/Fas mutants, and pathology is similar to that of C4/Fas double mutants

growth/size/body

enlarged spleen ( J:127292 )

• spleen mass is significantly increased relative to C3-null, Fas^lpr or single Fas^lpr mutants at 17 weeks of age