Phenotypes for C3 Fas MGI:3800669 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	C3^tm1Crr/C3^tm1Crr Fas^lpr/Fas^lpr
Genetic Background	involves: 129S4/SvJae * C57BL/6 * MRL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3^tm1Crr mutation (3 available); any C3 mutation (100 available)
Fas^lpr mutation (39 available); any Fas mutation (83 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:127292 )

N	• mutant and Fas^lpr spleens and lymph nodes do not significantly differ in weight at 10 or 13 weeks; at 17 weeks, LN mass is elevated but not significantly • lack of autoantibodies (ANA, anti-dsDNA) is observed

decreased susceptibility to autoimmune disorder ( J:127292 )

renal/urinary system

abnormal renal glomerulus morphology ( J:127292 )

• pathology score is minimally increased relative to B6.MRL-Fas^lpr mutants, but no IgG deposition is observed in kidneys

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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