Phenotypes Associated with This Genotype

Genotype
MGI:3800459

• Allelic Composition: Fas^lpr/Fas^lpr; Tg(CD2-Foxj1)#Stlp/0
• Genetic Background: MRL.Cg-Fas^lpr Tg(CD2-Foxj1)#Stlp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

salivary gland inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

enlarged spleen ( J:122222 )

• reduced lymphadenopathy is observed compared to non-transgenic Fas^lpr mice

increased double-negative T cell number ( J:122222 )

• diminished accumulation of CD3+ CD4- CD8- B220+ double negative T cells is observed in peripheral lymphoid organs

decreased CD4-positive, alpha-beta T cell number ( J:122222 )

• peripheral CD4 counts are 8- to 10-fold reduced

abnormal T cell physiology ( J:122222 )

• increased numbers of mature CD4+ thymocytes show defective migration in response to CCL19 in vitro, suggesting impaired ability to emigrate from the thymus

enlarged lymph nodes ( J:122222 )

• reduced lymphadenopathy is observed compared to non-transgenic Fas^lpr mice

decreased susceptibility to systemic lupus erythematosus ( J:122222 )

• double mutant mice display protection against murine lupus (reduced lymphadenopathy, autoantibody production and end-organ disease)

increased anti-nuclear antigen antibody level ( J:122222 )

• anti-DNA autoantibodies are produced; however, these autoantibodies are not high affinity anti-dsDNA antibodies and likely only low affinity anti-ssDNA antibodies are present

liver inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

kidney inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

lung inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

hematopoietic system

enlarged spleen ( J:122222 )

• reduced lymphadenopathy is observed compared to non-transgenic Fas^lpr mice

increased double-negative T cell number ( J:122222 )

• diminished accumulation of CD3+ CD4- CD8- B220+ double negative T cells is observed in peripheral lymphoid organs

decreased CD4-positive, alpha-beta T cell number ( J:122222 )

• peripheral CD4 counts are 8- to 10-fold reduced

abnormal T cell physiology ( J:122222 )

• increased numbers of mature CD4+ thymocytes show defective migration in response to CCL19 in vitro, suggesting impaired ability to emigrate from the thymus

renal/urinary system

kidney inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

endocrine/exocrine glands

salivary gland inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

digestive/alimentary system

salivary gland inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

liver/biliary system

liver inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

respiratory system

lung inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

growth/size/body

enlarged spleen ( J:122222 )

• reduced lymphadenopathy is observed compared to non-transgenic Fas^lpr mice