Phenotypes Associated with This Genotype

Genotype
MGI:3800140

• Allelic Composition: Fas^lpr/Fas^lpr; Pou2af1^tm1Pmt/Pou2af1^tm1Pmt
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:125114 )

N • at 7 months, all double mutants are still alive compared to extensive mortality observed in Fas single mutants by this age

immune system

decreased plasma cell number ( J:125114 )

• number of splenic IgG-secreting cells is dramatically lower than in Fas single mutants

• number of bone marrow IgG-secreting cells is dramatically lower than in Fas single mutants

increased B cell number ( J:125114 )

• in bone marrow, numbers of CD19+IgM- and CD19+IgD- B cells is increased

abnormal T cell number ( J:125114 )

• accumulation of B220+CD3+ cells in spleens and lymph nodes is markedly reduced compared to Fas single mutants

decreased immunoglobulin level ( J:125114 )

• serum immunoglobulin levels are significantly reduced compared to Fas single mutants and are similar to Pou2af1-null mice

• serum level of IgA is reduced but not to same extent as IgG

• IgM production is decreased

autoimmune response ( J:125114 )

• mice do not develop autoantibodies (anti-dsDNA or any IgG antinuclear autoantibodies)

hematopoietic system

hematopoietic system phenotype ( J:125114 )

N • splenic immature and mature B cell numbers are not reduced (a slight increase is observed)

decreased plasma cell number ( J:125114 )

• number of splenic IgG-secreting cells is dramatically lower than in Fas single mutants

• number of bone marrow IgG-secreting cells is dramatically lower than in Fas single mutants

increased B cell number ( J:125114 )

• in bone marrow, numbers of CD19+IgM- and CD19+IgD- B cells is increased

abnormal T cell number ( J:125114 )

• accumulation of B220+CD3+ cells in spleens and lymph nodes is markedly reduced compared to Fas single mutants

decreased immunoglobulin level ( J:125114 )

• serum immunoglobulin levels are significantly reduced compared to Fas single mutants and are similar to Pou2af1-null mice

• serum level of IgA is reduced but not to same extent as IgG

• IgM production is decreased

renal/urinary system

abnormal renal glomerulus morphology ( J:125114 )

• no IgG or C3 deposition is observed, but crescent formation and enlargement of glomeruli is observed

• no inflammation is observed

glomerular crescent ( J:125114 )

• crescent formation is observed

renal glomerulus hypertrophy ( J:125114 )

• enlargement of glomeruli is observed