Phenotypes Associated with This Genotype

Genotype
MGI:3799744

• Allelic Composition: Fas^lpr/Fas^lpr; Tlr9^tm1Aki/Tlr9^tm1Aki
• Genetic Background: B6.Cg-Tlr9^tm1Aki Fas^lpr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:135036 )

• 66% survival at 24 weeks

hematopoietic system

enlarged spleen ( J:135036 )

• spleens are 5-fold heavier than in MRL/MpJ-Fas^lpr mice

increased double-negative T cell number ( J:135036 )

• dramatically increased compared to wild-type; increased relative to Tlr9 and Fas mutants

increased IgG level ( J:135036 )

• total levels are higher than wild-type or Fas^lpr mice

decreased IgM level ( J:135036 )

• lower than in Fas^lpr mice

immune system

enlarged spleen ( J:135036 )

• spleens are 5-fold heavier than in MRL/MpJ-Fas^lpr mice

increased double-negative T cell number ( J:135036 )

• dramatically increased compared to wild-type; increased relative to Tlr9 and Fas mutants

increased IgG level ( J:135036 )

• total levels are higher than wild-type or Fas^lpr mice

decreased IgM level ( J:135036 )

• lower than in Fas^lpr mice

enlarged lymph nodes ( J:135036 )

• generalized lymphadenopathy

• axillary and inguinal lymph node weights are greater than in Fas^lpr mice (by >5-fold)

autoimmune response ( J:135036 )

• autoantibodies such as anti-ssDNA, anti-dsDNA, anti-cardiolipin, and anti-IgG are detected, and levels are not different from Fas mutants

glomerulonephritis ( J:135036 )

• interstitial lymphoid infiltration is observed at 13 weeks

• mesangial proliferation is greater than in Fas single mutants

homeostasis/metabolism

increased urine protein level ( J:135036 )

• increased more from 13 to 24 weeks than in Fas single mutants but not significantly so

renal/urinary system

increased urine protein level ( J:135036 )

• increased more from 13 to 24 weeks than in Fas single mutants but not significantly so

glomerulonephritis ( J:135036 )

• interstitial lymphoid infiltration is observed at 13 weeks

• mesangial proliferation is greater than in Fas single mutants

renal glomerular immunoglobulin deposits ( J:135036 )

• glomerular IgG deposits that are exclusively mesangial are more severe than in Fas single mutants

growth/size/body

enlarged spleen ( J:135036 )

• spleens are 5-fold heavier than in MRL/MpJ-Fas^lpr mice