Phenotypes Associated with This Genotype

Genotype
MGI:3799736

• Allelic Composition: Fas^lpr/Fas^lpr; Il4^tm1Cgn/Il4^tm1Cgn
• Genetic Background: MRL.Cg-Il4^tm1Cgn Fas^lpr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

lacrimal gland inflammation ( J:132514 )

• dacryoadenitis, characterized by multiple foci of mononuclear inflammatory cells

• predominant cell type in infiltrate at various ages is CD4+ T cells (66%); CD8+ T cells make up 16% of infiltrate

• B cells are somewhat less abundant in infiltrates (18%) than in double mutants

glomerulonephritis ( J:132514 )

• less severe than MRL/MpJ-Fas^lpr mice at 3 and 5 months

renal/urinary system

glomerulonephritis ( J:132514 )

• less severe than MRL/MpJ-Fas^lpr mice at 3 and 5 months

vision/eye

lacrimal gland inflammation ( J:132514 )

• dacryoadenitis, characterized by multiple foci of mononuclear inflammatory cells

• predominant cell type in infiltrate at various ages is CD4+ T cells (66%); CD8+ T cells make up 16% of infiltrate

• B cells are somewhat less abundant in infiltrates (18%) than in double mutants

endocrine/exocrine glands

lacrimal gland inflammation ( J:132514 )

• dacryoadenitis, characterized by multiple foci of mononuclear inflammatory cells

• predominant cell type in infiltrate at various ages is CD4+ T cells (66%); CD8+ T cells make up 16% of infiltrate

• B cells are somewhat less abundant in infiltrates (18%) than in double mutants