Analysis Tools
mortality/aging
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• overall survival is reduced compared to Faslpr homozygotes (median survival is 20 weeks vs 26 weeks for Fas mutants); renal lesions are severe at time of death
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immune system
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• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated
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• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated
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• severe neutrophil accumulation at 20 weeks is observed in kidneys
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• in kidney and cultured primary renal endothelial cells, levels of CCL2 are elevated compared to Faslpr controls at 20 weeks; expression levels are increased further upon LPS treatment of cells
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• at 20 weeks of age, kidneys display higher lesion scores than controls
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dermatitis
(
J:127199
)
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• double mutants show more rapid onset of cutaneous inflammation than Faslpr homozygotes
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hematopoietic system
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• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated
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• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated
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• severe neutrophil accumulation at 20 weeks is observed in kidneys
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renal/urinary system
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• at 20 weeks of age, severely affected glomeruli display capsular fibrosis and proliferation of the lining of Bowman's capsule
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• at 20 weeks of age, foot processes are fused
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• at 20 weeks of age, foot processes are diffusely effaced
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• lesions at 20 weeks are characterized by neutrophil infiltration of the glomerular tuft, proliferation of mesangial and endothelial cells, mild multifocal tubular atrophy, and interstitial mixed inflammatory cell accumulation
• more severely affected glomeruli have necrosis of large areas of the tuft, fibrin deposition, proliferation of lining of Bowman's capsule with fusion of the tuft (synechia), capsular fibrosis, and pericapsular lymphocyte accumulation
• subepithelial and subendothelial electron-dense deposits are detected
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• at 20 weeks of age, proliferation of endothelial cells is observed
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• at 20 weeks of age, cellularity of mesangium is moderately increased
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• at 20 weeks of age, kidneys display higher lesion scores than controls
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• at 20 weeks of age, markedly expanded mesangium due to mesangial matrix increase is observed
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• at 20 weeks of age, proliferation of lining of Bowman's capsule is observed
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• at 20 weeks of age, proliferation of lining of Bowman's capsule with fusion of the tuft (synechia) is observed
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• at 20 weeks of age, severely affected glomeruli exhibit fibrin deposition
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• at 20 weeks of age, mild multifocal tubular atrophy is observed
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• at 20 weeks of age, severely affected glomeruli display necrosis of large areas of the tuft
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• progressive decline in renal function is observed, during progression to end-stage renal disease
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cardiovascular system
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• at 20 weeks of age, proliferation of endothelial cells is observed
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integument
dermatitis
(
J:127199
)
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• double mutants show more rapid onset of cutaneous inflammation than Faslpr homozygotes
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cellular
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• at 20 weeks of age, cellularity of mesangium is moderately increased
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• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated
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• rolling is dramatically reduced, but not eliminated, in mutants compared to controls
• in mice chronically treated with anti-E-selectin antibodies, rolling is completely eliminated
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