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Phenotypes Associated with This Genotype
Genotype
MGI:3799519
Allelic
Composition
Tg(K6ODCtr)55Tgo/0
Genetic
Background
C57BL/6-Tg(K6ODCtr)55Tgo/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(K6ODCtr)55Tgo mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• in older mice, dermal cysts replace the subcutaneous fat layer

growth/size/body

endocrine/exocrine glands
• sebaceous glands are moderately hyperplastic

integument
• in older mice, dermal cysts replace the subcutaneous fat layer
• sebaceous glands are moderately hyperplastic
• by 1.5 months of age, mice exhibit generalized hair loss
• cysts replace the lower portion of the hair follicle
• mice exhibit a dilatation of the hair follicle infundibulum
• mice exhibit comedo-like structures associated with sebaceous glands
• disintegration of the lower portion of the hair follicle
• mice exhibit excessive nail growth
• by 1.5 months of age
• cysts replace the lower portion of the hair follicle
• some cysts have thick walls of stratified squamous epithelium filled with concentrically oriented cornified squames
• in older mice, dermal cysts replace the subcutaneous fat layer
• some cysts rupture and form foreign body granulomas
• as mice age their skin exhibits excessive growth resulting in wrinkling and folding

Mouse Models of Human Disease
OMIM ID Ref(s)
Atrichia with Papular Lesions; APL 209500 J:62356


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory