Mouse Genome Informatics
tg
    Tg(K6ODCtr)55Tgo/0
C57BL/6-Tg(K6ODCtr)55Tgo/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
adipose tissue
• in older mice, dermal cysts replace the subcutaneous fat layer

growth/size

endocrine/exocrine glands
• sebaceous glands are moderately hyperplastic

integument
• in older mice, dermal cysts replace the subcutaneous fat layer
• sebaceous glands are moderately hyperplastic
• by 1.5 months of age, mice exhibit generalized hair loss
• cysts replace the lower portion of the hair follicle
• mice exhibit a dilatation of the hair follicle infundibulum
• disintegration of the lower portion of the hair follicle
• mice exhibit excessive nail growth
• by 1.5 months of age
• cysts replace the lower portion of the hair follicle
• some cysts have thick walls of stratified squamous epithelium filled with concentrically oriented cornified squames
• in older mice, dermal cysts replace the subcutaneous fat layer
• some cysts rupture and form foreign body granulomas
• mice exhibit comedo-like structures associated with sebaceous glands
• as mice age their skin exhibits excessive growth resulting in wrinkling and folding

Mouse Models of Human Disease
OMIM IDRef(s)
Atrichia with Papular Lesions; APL 209500 J:62356