Phenotypes Associated with This Genotype

Genotype
MGI:3799494

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Fas^lpr/Fas^lpr
• Genetic Background: MRL.Cg-Apoe^tm1Unc Fas^lpr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased immunoglobulin level ( J:133606 )

• mice display greatly increased levels compared to wild-type controls or Apoe-null mice

increased susceptibility to systemic lupus erythematosus ( J:133606 )

increased autoantibody level ( J:133606 )

• IgG and IgM anti-oxidized LDL and anti-cardiolipin antibodies are increased compared to controls

increased anti-nuclear antigen antibody level ( J:133606 )

• mice display greatly increased levels compared to wild-type controls or Apoe-null mice

increased anti-double stranded DNA antibody level ( J:133606 )

• mice display greatly increased levels compared to wild-type controls or Apoe-null mice

homeostasis/metabolism

increased circulating cholesterol level ( J:133606 )

• significantly increased relative to wild-type controls at 24 weeks of age or Fas-single mutants

cardiovascular system

increased susceptibility to atherosclerosis ( J:133606 )

• modest increase in total area of lipid deposits in aorta compared to Apoe-null mice

hematopoietic system

increased immunoglobulin level ( J:133606 )

• mice display greatly increased levels compared to wild-type controls or Apoe-null mice