Phenotypes Associated with This Genotype

Genotype
MGI:3799477

• Allelic Composition: Tg(K6ODCtr)55Tgo/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased subcutaneous adipose tissue amount ( J:29098 )

• after three months of age, dermal cysts replace the subcutaneous fat layer

growth/size/body

decreased body weight ( J:29098 )

• at birth

dermal cyst ( J:29098 )

• mice exhibit follicular cysts in the dermis

• in mice older than 3 months, cysts are very large and replace the subcutaneous fat layer

cellular

increased keratinocyte apoptosis ( J:133302 )

• in culture, primary keratinocytes undergo premature cell death via apoptosis compared to wild-type cells

• increased cell density prolongs primary keratinocyte cell life in culture but does not prevent premature death

• however, treatment with DFMO blocks cell death in cultured primary keratinocytes

neoplasm

increased skin tumor incidence ( J:29098 )

• mice develop skin tumors (squamous neoplasms) at a higher rate than wild-type mice

• however, squamous cell carcinomas are not observed

increased keratoacanthoma incidence ( J:29098 )

• mice develop keratoacanthoma-like lesions

increased skin papilloma incidence ( J:29098 )

• mice develop well-differentiated papillomatous lesions

• skin tumors are found on the tail, face and ears

endocrine/exocrine glands

sebaceous gland hyperplasia ( J:29098 )

• sebaceous glands near dermal cysts are moderately hyperplastic

integument

decreased subcutaneous adipose tissue amount ( J:29098 )

• after three months of age, dermal cysts replace the subcutaneous fat layer

increased keratinocyte apoptosis ( J:133302 )

• in culture, primary keratinocytes undergo premature cell death via apoptosis compared to wild-type cells

• increased cell density prolongs primary keratinocyte cell life in culture but does not prevent premature death

• however, treatment with DFMO blocks cell death in cultured primary keratinocytes

sebaceous gland hyperplasia ( J:29098 )

• sebaceous glands near dermal cysts are moderately hyperplastic

dermal cyst ( J:29098 )

• mice exhibit follicular cysts in the dermis

• in mice older than 3 months, cysts are very large and replace the subcutaneous fat layer

alopecia ( J:29098 )

• despite a normal first hair cycle, mice exhibit hair loss at 2 to 3 weeks of age

• mice exhibit complete hair loss by 2 months of age

• hair loss is a dominant phenotype

long nails ( J:29098 )

• mice exhibit excessive nail growth

absent hair follicles ( J:29098 )

• after 2 months of age

absent vibrissae ( J:29098 )

• by 2 months of age

oily skin ( J:29098 )

• develops with age

wrinkled skin ( J:29098 )

• develops with age

increased skin tumor incidence ( J:29098 )

• mice develop skin tumors (squamous neoplasms) at a higher rate than wild-type mice

• however, squamous cell carcinomas are not observed

increased keratoacanthoma incidence ( J:29098 )

• mice develop keratoacanthoma-like lesions

increased skin papilloma incidence ( J:29098 )

• mice develop well-differentiated papillomatous lesions

• skin tumors are found on the tail, face and ears