Phenotypes Associated with This Genotype

Genotype
MGI:3799457

• Allelic Composition: Tg(Trp53R172L)4491Jmr/0
• Genetic Background: FVB/N-Tg(Trp53R172L)4491Jmr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

neoplasm ( J:56433 )

N • despite expression of the transgene, mice do not exhibit an increase in spontaneous tumor rates

endocrine/exocrine glands

abnormal mammary gland growth during lactation ( J:56433 )

♀ • during lactation, mammary glands exhibit incomplete development with few normal lobuloalveolar structures compared to in wild-type mice

abnormal mammary gland physiology ( J:56433 )

♀ • mice exhibit increased mammary gland cell sensitivity to radiation induced apoptosis compared to in similarly treated wild-type mice

lactation failure ( J:56433 )

♀ • females fail to lactate resulting in reduced pup weight and increased pup mortality

integument

abnormal mammary gland growth during lactation ( J:56433 )

♀ • during lactation, mammary glands exhibit incomplete development with few normal lobuloalveolar structures compared to in wild-type mice

abnormal mammary gland physiology ( J:56433 )

♀ • mice exhibit increased mammary gland cell sensitivity to radiation induced apoptosis compared to in similarly treated wild-type mice

lactation failure ( J:56433 )

♀ • females fail to lactate resulting in reduced pup weight and increased pup mortality

abnormal hair follicle morphology ( J:56433 )

• mice exhibit follicular dilatation and comedo formation

dilated hair follicle ( J:56433 )

hair follicle comedo ( J:56433 )

skin lesions ( J:56433 )

• lesions in the hind quarter represent follicular dilatation and comedo formation