Tg(Trp53R172L)4491Jmr
Transgene Detail

Summary

• Symbol: Tg(Trp53R172L)4491Jmr
• Name: transgene insertion 4491, Jeffrey Rosen
• MGI ID: MGI:1929643
• Transgene: Tg(Trp53R172L)4491Jmr Location: unknown
• Alliance: Tg(Trp53R172L)4491Jmr page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Trp53R172L)4491Jmr expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Trp53 (MGI:98834)

• Mutation details: This transgene contains the rat whey acidic protein promoter (0.95 kb of 5' sequence) fused to a mouse Trp53 minigene that carries a transversion in codon 172 (CGC->CTC; "Arg172Leu"). Removal of the ts mutation in the original Trp53 minigene at codon 135 (Ala-Val) and introduction of the Arg-Leu mutation at amino acid 172 were accomplished using recombinant PCR mutagenesis. (J:56433)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:56433 Li B, et al., Preferential overexpression of a 172Arg-->Leu mutant p53 in the mammary gland of transgenic mice results in altered lobuloalveolar development. Cell Growth Differ. 1994 Jul;5(7):711-21
• All: 3 reference(s)