Phenotypes Associated with This Genotype

Genotype
MGI:3799212

• Allelic Composition: Fasl^gld/Fasl^gld
• Genetic Background: C3H/HeJ-Fasl^gld

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell morphology ( J:8267 )

• lymph node cells (T cell origin) are abnormal; cells are Ly-2^-/L3T4^-/surface Ig^-

abnormal T cell physiology ( J:8267 )

• cells do not generate CTL in response to stimulation with alloantigens

abnormal T cell proliferation ( J:8267 )

• cells do not proliferate in response to stimulation with alloantigens

homeostasis/metabolism

abnormal interleukin level ( J:8267 )

• stimulation with concanavalin A does not induce cells to produce Il2

immune system

abnormal T cell morphology ( J:8267 )

• lymph node cells (T cell origin) are abnormal; cells are Ly-2^-/L3T4^-/surface Ig^-

abnormal T cell physiology ( J:8267 )

• cells do not generate CTL in response to stimulation with alloantigens

abnormal T cell proliferation ( J:8267 )

• cells do not proliferate in response to stimulation with alloantigens

abnormal interleukin level ( J:8267 )

• stimulation with concanavalin A does not induce cells to produce Il2

nervous system

decreased neuron apoptosis ( J:124252 )

• very low levels of apoptosis (15%) compared to wild-type (60%) are seen when cortical neurons are treated with Abeta25-35 or Abeta1-40 peptides

• neuron viability is comparable to wild-type when grown in absence of Abeta or if treated with KCN which induces necrotic cell death

cellular

decreased neuron apoptosis ( J:124252 )

• very low levels of apoptosis (15%) compared to wild-type (60%) are seen when cortical neurons are treated with Abeta25-35 or Abeta1-40 peptides

• neuron viability is comparable to wild-type when grown in absence of Abeta or if treated with KCN which induces necrotic cell death

abnormal T cell proliferation ( J:8267 )

• cells do not proliferate in response to stimulation with alloantigens