Phenotypes Associated with This Genotype

Genotype
MGI:3799204

• Allelic Composition: Fas^lpr/Fas^lpr
• Genetic Background: AK.MRL-Fas^lpr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

lymph node hemorrhage ( J:7454 )

• larger lymph nodes often show extensive hemorrhage

increased immunoglobulin level ( J:7454 )

• IgG and IgM levels are modestly increased in serum at 6 months

enlarged lymph nodes ( J:7454 )

• nodes are 6 times normal size

lymph node necrosis ( J:7454 )

• larger lymph nodes often show extensive necrosis

increased autoantibody level ( J:7454 )

• increase in thymocytotoxic autoantibodies at 6 months is seen

increased anti-nuclear antigen antibody level ( J:7454 )

• mice have significantly increased levels of anti-ssDNA antibodies

increased anti-double stranded DNA antibody level ( J:7454 )

• antibodies are increased relative to controls

glomerulonephritis ( J:7454 )

• Background Sensitivity: immune complex glomerulonephritis develops by 1 year of age but is much milder than in MRL homozygotes

renal/urinary system

abnormal renal glomerulus morphology ( J:7454 )

• nephritic changes consist of focal increase in mesangial substance and mild mesangial proliferation

increased mesangial cell number ( J:7454 )

• mild mesangial proliferation

glomerulonephritis ( J:7454 )

• Background Sensitivity: immune complex glomerulonephritis develops by 1 year of age but is much milder than in MRL homozygotes

expanded mesangial matrix ( J:7454 )

• focal increase in mesangial substance

renal glomerular immunoglobulin deposits ( J:7454 )

hematopoietic system

increased immunoglobulin level ( J:7454 )

• IgG and IgM levels are modestly increased in serum at 6 months

cardiovascular system

lymph node hemorrhage ( J:7454 )

• larger lymph nodes often show extensive hemorrhage

cellular

increased mesangial cell number ( J:7454 )

• mild mesangial proliferation