mortality/aging
• median survival is 284 days, compared to 795 days for controls
(J:6638)
• 50% mortality is observed at 13.5 months with 90% mortality at 16 months, significantly reduced from wild-type
(J:7454)
• 64% survival at 24 weeks
(J:135036)
|
immune system
• larger lymph nodes often show extensive hemorrhage
|
• larger lymph nodes often show extensive necrosis
|
• IgG and IgM levels are increased in serum at 6 months
|
• by 4 months of age, lymph nodes are increased 10- to 20-fold
(J:6638)
• nodes are 13 times normal size
(J:7454)
• generalized lymphadenopathy
(J:135036)
|
• defect in Il2 activity begins during early life and worsens with age; spleen cells show no stimulated Il2 production upon stimulation with concanavalin A
|
• increase in thymocytotoxic autoantibodies at 6 months is seen
(J:7454)
• mice have elevated levels of anti-chromatin antibodies compared to double mutants
(J:135036)
|
• anti-nuclear antibodies are present at 6 months of age
(J:6638)
• mice have elevated levels of anti-chromatin (anti-nucleosome) antibodies compared to double mutants
(J:135036)
|
• antibodies are increased relative to controls
|
• Background Sensitivity: immune complex glomerulonephritis develops by 1 year of age but is much milder than in MRL homozygotes
(J:7454)
• interstitial lymphoid infiltration is observed at 6 months; glomerular IgG deposits that are exclusively mesangial are observed
(J:135036)
|
renal/urinary system
• nephritic changes consist of focal increase in mesangial substance and mild mesangial proliferation
|
• mild mesangial proliferation
|
• Background Sensitivity: immune complex glomerulonephritis develops by 1 year of age but is much milder than in MRL homozygotes
(J:7454)
• interstitial lymphoid infiltration is observed at 6 months; glomerular IgG deposits that are exclusively mesangial are observed
(J:135036)
|
• focal increase in mesangial substance
|
hematopoietic system
• IgG and IgM levels are increased in serum at 6 months
|
cardiovascular system
• larger lymph nodes often show extensive hemorrhage
|
cellular
• mild mesangial proliferation
|
• larger lymph nodes often show extensive necrosis
|
growth/size/body